Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell proliferation, cause DNA double-strand break and trigger caspase-mediated apoptosis through JNK/p38 pathways in human acute promyelocytic leukemia cells

Synthesis of ruthenium(II) complexes with 6-methyl-2-thiouracil Ruthenium(II) complexes with 6-methyl-2-thiouracil ligand, cis-[Ru(6m2tu)2(PPh3)2] (1) and [Ru(6m2tu)2(dppb)] (2), were obtained as previously described by Correa20. Briefly, synthesis of 1 and 2...